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Em fluxos de trabalho de pesquisa em uso clnico (RUO), o AOD9604 pode ser utilizado como uma sonda dentro dessas estruturas para examinar como a modulao do metabolismo lipdico se correlaciona com marcadores selecionados de vias metablicas sob condies experimentais controladas .7] Contexto de via/mecanismo O AOD9604 utilizado em estudos mecansticos para mapear a sinalizao e os parmetros bioqumicos associados ao metabolismo lipdico e funo do tecido adiposo

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Abstract Despite advances in immunotherapy, triple-negative breast cancer (TNBC) remains a major therapeutic challenge owing to its marked aggressiveness, low immunogenicity, and limited responsiveness to immune checkpoint blockade (ICB)

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Proteomic analysis has shown that x-ray repair cross-complementing protein 1 (XRCC1) K247 lactylation enhances its binding affinity for importin- (also known as Karyopherin-), facilitating nuclear translocation and promoting DNA damage repair in tumor cells