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Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract

& Schultz, C

10.1038/onc.2014.343 78 RossignolJ

The limitations of clinical endpoints further compound the problem

NMN-treated mice also maintained higher levels of food and water consumption compared to control mice, which suggested that NMN did not cause severe side effects, such as growth defect and loss of appetite (Mills et al., 2016)

Briefly, mice with a floxed allele of exon 5 Ppara were built up by using homologous recombination in ES cells and back-crossed with transgenic mice expressing Cre recombinase regulated by the albumin (Alb-Cre) promoters for at least eight generations to create hepatocyte-specific ( Ppara Hep ) knockout mice