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Animal and cellular experiments have shown that curcumin can bind to TLRs and participate in regulating downstream inflammatory signaling pathways such as MAPK, NF-B, and AP-1, significantly reducing levels of inflammatory mediators such as IL-1, IL-6, TNF-, NO, and iNOS, thus achieving anti-inflammatory effects [29,65]

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They were also found in different epithelia, organs, and secretions of glands (reviewed by [103] and [104])