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Theres still research to be done to understand exactly where it comes from, but there is a genetic element so it does tend to run in families

doi: 10.1515/med-2016-0072 149 YangY.LiuP

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Site-directed mutagenesis Site-directed mutagenesis of the GST clone was performed using a QuikChange mutagenesis kit (Stratagene) according to the manufacturers protocol

(2020) 7:163 doi:10.3389/fmolb.2020.00163