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217 ToledoJ

Korolczuk et al

PHGDH impairment has broad metabolic consequences, affecting serine availability, the TCA cycle anaplerosis, redox balance, energy metabolism, nutrient sensing, and cell signaling (59)

Five patients (5 out of 18) had abnormally high MMA levels and these ranged from 340 to 412 nmol l 1 (normal range: 73271 nmol l 1 )

doi: 10.1016/j.cell.2015.08.016 271 IshiiGOchiaiANeriS

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