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326,327 Quercetin activates Nrf2/Keap1 to reduce ROS, 328 while inducing ROS-dependent cell death in malignant cells, 329,330 underscoring its potential as both a chemopreventive and chemotherapeutic agent

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Hydrogen sulfide (H 2 S), similar to MG, has previously considered as a toxic metabolite, disrupting cell signaling processes, especially those involving ROS [26]

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Flavonoids, the compounds with anti-inflammatory and immunomodulatory properties, as promising tools in multiple sclerosis (MS) therapy: a systematic review of preclinical evidence