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Analysis of superposed structures of Mm SAHH with bound adenosine 54 and bound inosine showed no substantial differences in the architecture of the substrate binding pocket depending on the bound substrate (Supplementary Fig

The tissue was fixed in TEM fixative containing 2% glutaraldehyde and 2% formaldehyde in 0.1 M cacodylate buffer (pH 7.3) for 48 h, then washed with 0.1 M cacodylate buffer (pH 7.3)

Kesse-Guyot E

Additionally, some mechanistic inferences are based on observational data of metabolite levels or single-gene regulation, lacking causal validation via interventional experiments

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