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It has a decay-accelerating activity for the classical pathway C3 convertase and acts as a cofactor promoting factor I-mediated cleavage of C4b

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(1) poor gastrointestinal absorption, (2) high rates of metabolism, (3) inactivity of metabolic products, and (4) rapid elimination and clearance ( Several delivery techniques have been developed to overcome the pharmaco-kinetics predisposing to poor bioavailability of orally ingested curcumin, including adjuvants, nanoparticles, liposomes, and a self-nanoemulsifying drug delivery system (SNEDDS) ( in vivo response has been varied ( P -glycoprotein and CYP3A4 systems ( Regardless, curcumins substantial limitations have not stopped scientists from researching and enhancing its potential

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