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IV NAD, hyperbaric oxygen chambers, ozone therapies, chemotherapies, and radiations are all very pro-oxidative

Cell Membrane Inhibitors: Examples, Inhibition, Resistance, (2023)

Am J Physiol (1992) 262(6 Pt 1):L64761

doi: 10.3389/fcell.2024.1421566 Received 22 April 2024 Accepted 25 June 2024 Published 02 August 2024 Volume 12 - 2024 Edited by Kunihiro Tsuchida, Fujita Health University, Japan Reviewed by Agnese De Mario, University of Padua, Italy Ramona Meanti, University of Milano Bicocca, Italy Updates Copyright 2024 Fenili, Scaricamazza, Ferri, Valle and Paronetto

The PPP occurs in the cytoplasm, where glucose-6-phosphate dehydrogenase (G6PD) catalyzes the conversion of G6P to ribose-5-phosphate, a precursor for nucleotide/nucleic acid synthesis (Hay, 2016

However, excessive NO scavenging in conditions of elevated Hb concentrations in the MEJs can reduce NO bioavailability and induce endothelial dysfunction (Denton et al., 2021), increasing vascular resistance (Straub et al., 2014a)