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For most fibrillar collagens, the enzyme lysyl oxidase catalyzes the formation of covalent bonds between the ends of collagen molecules (Figs

Furthermore, standard extrapolation of the fomepizole dose that prevents JNK activation in mice to humans would suggest a human equivalent dose of about 4 mg/kg, more than 3 times lower than the standard 15 mg/kg loading dose used clinically

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Indeed, this LDHB-mediated three-step reaction would also explain why NADH production by LDHB-mediated lactate oxidation in the presence of NAD+ decreased in a dose-dependent manner upon addition of CoQ, i.e., the newly formed NADH (step 1) is immediately oxidized to NAD+ (step 2) in the presence of CoQ (Fig

Nagel RL, Gibson QH