(1) Cytosolic enzymes, (2) membrane bound enzymes
Cell Metab 2018;27:428-38
Ian Meyer, senior, Deans List, College of Engineering, electrical engineering
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Given GPX4s central position within the primary antioxidant defense against ferroptosis, mediated through the cystine/glutamate antiporter system (System Xc-) and GSH synthesis, it remains the predominant focus for targeted ferroptosis-inducing drugs
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