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Tabak BA, Young KS, Torre JB, Way BM, Burklund LJ, Eisenberger NI, et al

B12 is no exception

This metabolic switching is regulated by sirtuins, namely SIRT3 and SIRT2 repress the Warburg effect 342345 , while SIRT5 maintains glycolysis 346

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If results are weak into the remodelling phase and starting dose was sub-3.2 mg, a dose increase and protocol modification may be warranted