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PMCID: PMC5909471

We then created a total score by summing the 5 scales and compared outcomes based on treatment group and gender with separate Mann Whitney rank sums test due to the skewed distributions, using SPSS version 27 (Armonk, NY: IBM Corp)

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Long-Term Effects (3-6 Months and Beyond): Typically, the most dramatic improvements occur with continued treatment

The implication for clinical practice is that restoring youthful MOTS-c signaling might be a mechanistically legitimate target for longevity intervention

Beyond its established function in selenocysteine synthesis for the production of selenoproteins such as GPX4, selenide can now be viewed as an active participant in mitochondrial antioxidant defense