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[16] [21] Seek urgent medical attention call 999 or attend A&E if you develop severe, persistent abdominal pain, particularly if it radiates to the back (NHS)

Introduced in 1985, oxidative stress was found to be a source of significant cell damage that could undermine the quality of cell DNA and proteins

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CYP2E1 catalyzes the oxidation of APAP to NAPQI, a highly reactive metabolite inducing severe massive hepatocellular necrosis ( CYP2E1 knockout mice showed resistance to the APAP high dose-associated hepatotoxicity, suggesting that CYP2E1 is the major cytochrome P450 enzyme participating in APAP metabolism and toxicity ( CYP2E1 in APAP toxicity, CYP enzymes, notably CYP2E1 , generate ROS and lipid peroxidation (Veith and Moorthy, 2018)

Furthermore, free radicals could cause mitochondrial damages, followed by reduced energy production, and increased oxidative stress (6, 26)

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