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While some of these phenotypic changes are related to the alcohol-induced oxidative stress in the lung, chronic alcohol exposure also alters alveolar macrophage metabolism (76, 82)

Apart from the genetic mutations, other experiments have proven that it is the lack of taurine conjugation to the tRNALeu(UUR) that leads to MELAS syndrome

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For instance, inhibitors of ferroptosis, such as Ferrostatin-1, can reduce inflammatory responses in keratinocytes, which may be related to the modulation of Th17 cell functions (152)