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In AD-induced pluripotent stem cell (iPSC)-derived neurons, levels of other mitophagy-related proteins such as FUNDC1 and Bcl2L13 are also decreased, further confirming impaired autophagy in AD [63]

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This interlaboratory and inter-donor variability undermines reproducibility and complicates cross-study comparisons 156 , posing a major obstacle to the standardization of hiPSC-CMbased platforms