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Cryogenic electron microscopy studies suggest that human Hs HOP binds to all components of the HSP70HSP90GR complex via the TPR2A, TPR2B and C-terminal domains, but the TPR1 domain is not involved in complex formation or GR activation 26,37

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This pattern mirrors the consequences of HHEX deficiency, where HHEX KO inhibits efficient pancreatic fate acquisition and promotes hepatic marker expression in hPSC-derived endoderm 7