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Studies of the antioxidant pools in frataxin-depleted cultured human cells have shown significant decreases in reduced glutathione along with actin stress fibre disorganization [21], but this reduction in antioxidant pools have little or no impact on the cells under basal conditions

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In contrast, even modest weight loss in obese individuals following a hypocaloric diet increased circulating zinc to normal levels (89, 101, 109)

Dosage All participants (children and adults) received either the supplement or placebo, and the dosage was adjusted based on baseline measured body weight up to a maximum of 100 pounds (see Table 3)