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Given that ARID1A-negative cancer cells have been previously shown to be more susceptible to inhibition of glutathione synthesis compared to ARID1A-positive cancer cells, we next sought to determine whether EN25 selectively impairs cell viability of ARID1A-negative A2780 ovarian cancer cells, compared to ARID1A-positive RMG-1 ovarian cancer cells

The phase 1 trials were based on preclinical studies that were presented at the 2023 American Heart Association Scientific Sessions

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Sulforaphane, a diet-derived isothiocyanate enriched in broccoli and related crucifers, has been reported to decrease vascular inflammation by inactivating TNF/TNFR-induced downstream NF-B signaling as well as inhibiting IB degradation and eventually reducing the risk of vascular diseases in mice

Sci Trans Med (2014) 6(231):231ra49

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