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Consistent with these findings, a recent genome-wide CRISPR knockout screen revealed that the ubiquitin ligase complexes UBR4-KCMF1, UBR1, and UBR2 of the Arg/N-degron pathway recognize proteins that lack NatC-mediated N-terminal acetylation, promoting their degradation in human cells [267]

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doi: 10.1007/s11011-008-9099-0 88 Alva-SanchezCSanchez-HuertaKArroyo-HelgueraOAnguianoBAcevesCPacheco-RosadoJ

Trimethylamine-N-oxide (TMAO) and basic fibroblast growth factor (bFGF) are possibly involved in corticosteroid resistance in adult patients with immune thrombocytopenia