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Moderate instability promotes adaptation by enabling oncogene amplifications (e.g., ERBB2, CCND1, MYC) or loss of tumor suppressor loci, facilitating therapeutic escape, whereas excessive instability compromises viability

The Urano group reported the QuicGSH probe, elegantly taking advantage of the fast reversible reactions between GSH and a cationic silicon-rhodamine scaffold 38

PubMed, Sturza, Adrian, et al

Glu 12 C-H2

Documented observations within controlled laboratory research models Recorded observations in experimental models are primarily associated with glutathione-related redox signaling, oxidative stress markers, and intracellular antioxidant response behavior

Kameda M, Teruya T, Yanagida M, Kondoh H