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It was found that the maximal mean weight loss relative to placebo was -3.06, -6.15, -7.45, and -5.5kg after 1 year with mean weight regain +0.48kg, +0.91kg, +1.27kg, +0.43kg the following year, respectively

Annals of Thoracic Surgery 119(3):495-508, 2025

The first scenario was grape must from healthy grapes while the second was grape must enriched with laccase to reproduce what occurs when the grapes are infected with Botrytis cinerea