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These advantageous actions of the tested agents were accounted to their antioxidant, anti-inflammatory and anti-apoptotic properties, along with their abilities to modulate HMGB1/RAGE/JAK-2/STAT-3, PI3K/AKT/CREB/BDNF/TrkB, AMPK/SIRT-1/m-TOR and PERK/CHOP/GRP78/Bcl-2 hubs, as main contributors in the underlying pathophysiological mechanisms in MSG-induced ADHD-like behaviors (Graphical abstract)

A meta-analysis demonstrated that omega-3 fatty acid supplementation significantly reduces disease activity in adult SLE patients (with an average decrease of 0.9 points in SLEDAI scores) [100]

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Once a person becomes infected, early diagnosis of necrotizing fasciitis is notoriously difficult, with one study showing its misdiagnosed 71% of the time, according to the Agency for Healthcare Research and Quality

[64] claimed that if cereals used for making sourdough are grown conventionally, the sourdough starter usually has lower biodiversity than those using flour from organically grown cereals