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Smoothing inertia Under the hood, the national OD number is actually "smoothed." In epidemiology we could call it a cumulative sum of 12-month rolling windows

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10.1039/d2sc02708a 35 LabarrereC

SCFAs like butyrate exert anti-inflammatory and metabolic homeostasismaintaining effects by inhibiting histone deacetylases (HDACs) and activating G-proteincoupled receptors 12

Binding to these receptors initiates several metabolic pathways, including lipolysis, which is the breakdown of fat 4,5

The absence of serious adverse events, treatment-related withdrawals, IGF-1 elevation, glucose metabolism impairment, or immunogenic responses represents a favorable safety foundation