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[DOI] [PMC free article] [PubMed] [Google Scholar] 293.Rumack B, Heard K, Green J, Albert D, Bucher-Bartelson B, Bodmer M, Sivilotti MLA, Dart RC

Most of our patients start with what we call an initial loading dose

[16] [17] Whereas the latter directly act on the dopamine transporter (DAT) to inhibit the reuptake and/or induce the release of dopamine, bromantane instead acts via indirect genomic mechanisms to produce a rapid, pronounced, and long-lasting upregulation in a variety of brain regions of the expression of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) (also known as DOPA decarboxylase), key enzymes in the dopamine biosynthesis pathway

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Broadly, the trend distribution was as follows: decreasing trend (46.10% non-significative and 30.30% significative, expressed as average values) and increasing trend (20.90% non-significative and 2.70% significative) (see Table S9), thereby confirming decreasing trend is predominant over the studied period (76.40% decreasing vs 23.60% increasing)