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The reference compound MK-801 can restore L-glutamate-induced toxicity and cell death as assessed by LDH and MTT assay, respectively (n=6 per group)

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[22] Ironsulfur clusters [edit] Ironsulfur clusters are complexes of iron and sulfur atoms held within proteins by cysteinyl residues

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Overproduction of reactive oxygen species (ROS) in the nucleus pulposus cells (NPCs) is a critical contributor to the progression of IDD through increasing oxidative stress in the microenvironment of the extracellular matrix (ECM) 5 , leading to ferroptosis and long-term persistent inflammation 6,7 , which would cause the loss of structure and function in the intervertebral disc (IVD) ultimately