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Voltage-gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin-induced peripheral neurotoxicity: Results from a prospective multicenter study

J Med Biochem 2015;34(2):151-159

Dec 2019;8(6):678-685

These enzymes function as druggable metabolic nodes that regulate the size of the ubiquinol pool and thus the capacity of cells to buffer lipid peroxidation

NLRP3 activation in cardiomyocytes has been shown in pre-clinical models to trigger spontaneous AF, and is upregulated in the atrial cardiomyocytes of patients with post-operative AF, implying that increased activation of this signaling pathway acutely and during convalescence may be an important contributing factor to paroxysmal AF and its consequences (120, 200)

Research from Oxford University demonstrates that mepolizumab not only reduces eosinophil counts but reverses the primed hyperactive state these cells develop in severe asthma. This treatment is specifically designed for patients with severe eosinophilic asthma , defined as having blood eosinophil levels of 150 cells per microliter or higher despite using high-dose inhaled corticosteroids plus additional controllers