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Bechtel, T.J

2013;8:e56337

There is thus a widely recognized need for, and it would be highly advantageous to have novel antioxidant compounds and methods for use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and Creutzfeldt-Jakob's diseases and in treating conditions of peripheral tissues, such as acute respiratory distress syndrome, amyotrophic lateral sclerosis, atheroscierotic cardiovascular disease and multiple organ dysfunction, which compounds act as oxygen scavengers to lower the oxidative stress within and in the vicinity of affected cells and eventually to stop cell death which is associated with oxidative stress in the brain and/or peripheral tissues

Besides, to further confirm the consistency and accuracy, we established another test cohort from the TCGA database for internal validation

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Decline in available NADPH, a cofactor required by calcium pump may also disrupt calcium homeostasis