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2 The redox state of the cytoplasmic [NADPH]/[NADP + ] and [NAD + ]/[NADH] are linked in cells with high malic enzyme 1 (ME1) and LDH activities In cells with at least moderate cytoplasmic malic enzyme 1 (ME1) activity, the malate/pyruvate is proportional to the cytoplasmic [NADPH]/[NADP + ] (Veech et al., 2019)

Based on this data, the authors supposed involvement of this protein in HaCaT cells carcinogenesis

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Collectively, our data provides mechanistic insight into the behaviour of Cagri as a dual CTR and AMYR agonist peptide

MA at ST36 and GV20 promoted cognitive function and protected neurons in CCH rats via downregulating the expression of TNF- and IL-6 and reducing the number of microglia in the hippocampus by activating the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway by targeting 7nAChR (90)

Faerron Guzman Planetary Health Alliance, Johns Hopkins University University of Maryland Baltimore Graduate School Catherine Machalaba The Nature Conservancy Cedric Colmar Director of partnerships, international and European affairs - VetAgro Sup Moderators: Olakunle Alonge, Anna Hellova Implementation research has a potential to tackle a variety of global health challenges