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doi: 10.2174/0929867331666230727103553 19 AskarizadehM.EsfandiariN.HonarvarB.SajadianS

These anti-inflammatory effects parallel our pharmacogenomics strategy, indicating that leucovorin downregulates the gene coding for Interferon gamma ( IFNG ), a key inflammatory cytokine, and our results in adult remyelinating lesions indicating that leucovorin acts in microglia/macrophages accelerating the transition from pro-inflammatory to pro-regenerative profiles

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Both PTH-based peptides highlight an important principle in peptide pharmacology: dosing pattern matters as much as the compound itself