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Intratumor heterogeneity: evolution through space and time

Clinical trials (NCT01967810, NCT01480583, NCT02048059, and NCT01497665), such as those investigating ANG1005 and GRN1005, have explored LRP1-targeting therapeutics, where paclitaxel molecules are covalently linked to Angiopep-2 to enhance BBB penetration and tumor uptake while circumventing P-gp-mediated drug efflux (Table 7) [169,170]

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139 However, Ishteyaque et al 126 found that increased CYP2E1 levels stimulates the unfolded protein response and the upregulation of ERs-related proteins, suppresses the expression of B-cell lymphoma 2 (BCL2), and promotes HCC development via glucose-related protein 78/activating transcription factor 6 and CCAAT/enhancer-binding protein homologous protein signaling

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Typically, after approximately four treatment sessions spaced 4-6 weeks apart, patients will begin to see the full effects of the PRP therapy about five to six months after starting treatment