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6 Challenges and solutions of anti-angiogenic targeted therapy for GC Anti-angiogenic drugs target various aspects of tumor angiogenesis to block the formation of blood vessels to cut off the nutrient and supply to tumor cells, resulting in a hypoxic microenvironment (164)

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therefore, our titration conditions did not have the sensitivity to identify the IC 50 without large errors

Individuals with the 677T allele and the 1298AC genotype had a higher susceptibility to MS than those with the wild-type genotype [101]

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Notes CONFLICT OF INTEREST No potential conflict of interest relevant to this article was reported