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6E) and ROS (Fig

This pattern is different from other types of RCD that have been previously observed

However, even in the absence of specific signs or symptoms of connective tissue diseases, serological autoimmune tests should be performed in all patients.2 In fact, positive anti-nuclear antibodies or rheumatoid factor can be detected in up to 20% of IPF cases.3 The presence of serum specific IgG against the antigens that can most often cause hypersensitivity pneumonitis should be assessed systematically, since its clinical manifestations are occasionally similar to those of IPF

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