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Sarcopenia and sarcopenic obesity

The majority of alcohol is oxidized in the cytosol by aldehyde dehydrogenase (ADH), in peroxisomes by CAT, and in microsomes and mitochondria by CYP2E1 via the microsomal ethanol-oxidizing system (MEOS) before toxic acetaldehyde is further detoxified by mitochondrial aldehyde dehydrogenase 2 (ALDH2) [187, 188]

J Biol Chem 1952

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Vitamin D can cause kidney and cardiovascular damage, nausea, irritability and even coma

The results of long COVID investigations cautiously suggest that impaired metabolism and neuronal dysfunction may play a role in mental fatigue, similar to hypotheses for ME/CFS