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Post-translational Modification During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine

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Further research could focus on targeting genes such as CRY, Per, Rev-Erb, and ROR alpha through loss-and-gain experiments (e.g., using Rev-Erb alpha agonists), which may lead to novel drug targets for treating insulin resistance and hepatic metabolism

Once exported, SNO could act to cross-regulate the export of ATP by RBCs, since inhibitory S-nitrosylation of Px1 has been described

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