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Assessment of clinical response to Janus kinase inhibition in patients with familial chilblain lupus and TREX1 mutation

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318 Another study evaluated the efficacy of CP31398 in a transgenic UPII-SV40T mouse model of human transitional cell carcinoma (TCC), and the results showed that mice that received CP31398 suppressed invasive TCC

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Reasons for the different results may include the limited sample sizes, the assays for detection, different stages of the disease, and the difference between local and systemic states of oxidative stress

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Nrf2 is made up of 650 amino acid residues and has a molecular weight of 96118 kDa because of posttranslational changes such as phosphorylation (Moi et al., 1994

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