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The NICE Clinical Knowledge Summary for vitamin B12 deficiency outlines specific treatment schedules: for patients without neurological symptoms, hydroxocobalamin 1 mg intramuscularly three times a week for 2 weeks

in particular, liver dysfunction was significantly more severe in these patients than in those who were not supplemented (124)

Doseresponse curves of CRC cells treated with SMART1 (20 nM) in combination with DMSO or AR12 at indicated concentrations (right)

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Upon encountering an unfavorable stimulus, unfolded or incorrectly folded proteins have the ability to activate the unfolded protein response (UPR) signaling pathway, which then transports them out of the ER where they are degraded by the proteasome (173, 174)