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The results have been consistently promising across multiple tissue types and organ systems, though large-scale human clinical trials remain limited

Effect of low-calorie versus low-carbohydrate ketogenic diet in type 2 diabetes

Necrotic cells release damage-associated molecular patterns such as high-mobility group box 1 protein and DNA fragments, which cause the recruitment of inflammatory cells (eg, neutrophils) and cytokine generation, eventually resulting in sterile inflammation

Support Pregnancy: Folic acid (B9) is essential for fetal development, especially in early pregnancy

depression patients demonstrate characteristic changes including decreased Faecalibacterium and increased Actinobacteria and Enterobacteriaceae (Lin et al., 2025)

The research methods mainly include expanding existing metabolic pathways and constructing novel metabolic pathways