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In dopaminergic neurodegenerative disorders, a key pathogenetic event is also the inactivation of tyrosine hydroxylase, a rate-limiting enzyme in dopamine and norepinephrine biosynthesis, by oxidative injury (Di Giovanni et al., Mutations of the antioxidant superoxide dismutase gene (SOD1) are linked to about one fifth of the cases of familial amyotrophic lateral sclerosis, a degenerative disorder of motor neurons

Chronic copper overload or excessive copper accumulation can lead to oxidative damage and disrupt cellular processes

Recombinant human endostatin combined with radiotherapy in the treatment of brain metastases of non-small cell lung cancer

These analyses provide a theoretical basis and guidance for the discovery and study of more natural product inducers in the future

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Barch DM, Braver TS, Carter CS, Poldrack RA, Robbins TW