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Federicia [22], who reviewed the treatment criteria followed in different studies, concluded oral administration to be effective, but recommended further work to confirm this

Selection of the best combination of spectral filters for each biochemical parameter in an ensemble mode using ANN When the filter combination optimization for each parameter was performed, it was possible to define that the most frequent spectral filters for smoothing, baseline correction, normalization, and others were WDS, AsLS, SNV, and 1 st quadratic derivative, respectively (Table 3)

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[PubMed: 2929565] (56 year old man and 37 year old woman developed acute liver failure after ingestion of bottle of Nyquil [420 mL: 14 g acetaminophen in 25% alcohol] over 1-3 days [bilirubin 1.3 and 12.5 mg/dL, AST 8285 and 2413 U/L, Alk P 249 and 53 U/L], both survived)

Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

PMID 8719443