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The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases

This inhibition prevents the conversion of nicotinamide into 1-methylnicotinamide, effectively rescuing the NAD salvage pathway

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The enzymatic activity of Grx1 and Grx2 were observed to increase in cell lysates treated with OH Py 2 N 2 (1100 m) in a dose-dependently manner (Figure 4B) along with the protein levels of Grx1 and Grx2 (Figure 4A)