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For example, metformin therapy significantly modifies serum phosphatidylcholine profiles (notably acyl-alkyl PC species) in T2DM (117), potentially confounding the interpretation of insulin resistance-associated metabolic signatures

Translating findings from mice to humans would require careful dose scaling and clinical validation to establish safety and efficacy in SLE patients

Our findings highlight how dysregulated glutamate transporter EAAT3 enhances glutamate uptake, thereby facilitating cystine uptake and GSH synthesis

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