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Section 419.66(d)(1), the first cost significance requirement, provides that the estimated average reasonable cost of devices in the category must exceed 25 percent of the applicable APC payment amount for the service related to the category of devices

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doi: 10.1002/JLB.3RU1018-378RR 14 JablonskiKAAmiciSAWebbLMRuiz-RosadoJPopovichPGPartida-SanchezSet al

Most injection plans use a short loading phase, then maintenance every 13 months depending on the cause (NHS