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Cohen LH, Vamos E, Heinrichs C, Toppet M, Courtens W, Kumps A, Mardens Y, Carlsson B, Grillner L, Larsson A: Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency

We have already seen examples: transplanting microbiomes from patients into mice to induce disease features, or adding/removing single species to gauge their impact on pathology