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Similarly, garcinia acid ( + influx by blocking VGCCs (310)

Interestingly, the interaction of Sec24C and SLC7A11 is enhanced by VRK2-mediated phosphorylation, which is consistent with previous studies showing that the phosphorylation of Sec24C determines its affinity to cargo proteins and intracellular transport of cargoes [25]

Curcumin operates through complementary mechanisms, disrupting lysosomal membrane integrity via hydrophobic insertion into lipid bilayers

A significant portion of potent herbal extracts are lipophilic (oil-soluble), making them difficult to dissolve in the standard aqueous saline used in traditional drops [350,351,352]

Pravin Phadatare, Jayanta Debnath Lysosomal inhibition elicited by palmitoyl-protein thioesterase 1 (PPT1) inhibitors such as DC661 can produce cell death, but the mechanism for this is not completely understood

Key representatives include gallic acid (GA) (a hydroxybenzoic acid found in berries, tea, and other sources) and caffeic acid (a hydroxycinnamic acid abundant in coffee, apples, and herbs), along with others like ferulic and p-coumaric acids (148)