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DSIP is now one of the most studied nonapeptides for which the primary receptor has never been identified

116 More recently, the transcription factor Forkhead box class O1 (FoxO1) was found to be required for exercise-induced physiological cardiac hypertrophy, but was not necessary in mediating PI3K activation-induced physiological hypertrophy in vivo

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Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat

The researchers behind the phase 2 trial specifically designed the titration schedule to prevent this, and the data validated their approach