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Early nanoformulations, such as liposomes and polymeric micelles, were primarily designed to improve solubility and pharmacokinetics and to exploit enhanced vascular permeability and impaired lymphatic drainage for passive tumor accumulation [18, 20, 21]

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On day 14 relative to the onset of supplementation, all horses were weighed to balance treatment groups by BW

Upon completion of reaction, the HAMA solution is transferred into a dialysis membrane (MWCO 7,000 Da, Solarbio) and dialyzed against deionized water at ambient temperature for 3 days