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The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol, acetaminophen

PLs are the fundamental constituents of biological membranes

A significant proportion of moderate or partially deficient patients (Class 3) still developed severe hyperbilirubinemia that require prompt phototherapy intervention (14), showing that higher residual enzyme activity level does not confer more protection against hyperbilirubinemia

Given its established roles across various fields and its strong association with the pathogenesis of diverse diseases, including kidney diseases, respiratory diseases and cardiovascular diseases, understanding the molecular role of GPX3 may provide valuable insights for predicting disease prognosis and identifying new therapeutic targets for diagnostic and treatment strategies