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After correcting for multiple comparisons, our analysis identified 19 individual CpGs and 24 DMRs significantly associated with the RI in the HBI cohort

The augmentation of reductive Ce (III) of BP@CeO x nanozymes could be attributed to the P atoms coordinating with the solubilized oxygen to form oxidized phosphorus in the microenvironment, which may effectively provide amounts of reduced Ce (III) to Ce (III)/Ce (IV) antioxidative pairs to maintain long-term ROS-scavenging ability

Consistent with the above bioinformatic analyses, these results further confirm that human IDD is characterized by a redox imbalance, ferroptosis activation, and inflammatory stress, suggesting an intricate interplay among these factors throughout the IDD cascade

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doi: 10.2147/COPD.S89849 171 WuF.WuriG.FangB.ShiM.ZhangM.ZhaoL.et al