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PMID 25463043

The variants associated with the combined PDFF and NAFL at genome-wide significance (GWS) were nominally significant for both phenotypes ( P 0.19) are a splice-region variant in HSD17B13 , rs72613567[TA], which has been reported as being associated with NASH 21 , and a missense variant p.Glu366Lys in SERPINA1 , which causes 1 -antitrypsin deficiency 36

This dependency creates therapeutic vulnerabilities that can be exploited to selectively impair tumor survival, overcome drug resistance, and enhance sensitivity to conventional therapies (Fig

Journal of Clinical and Translational Hepatology , 9 (1), 40

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